ZOLINZA may cause serious side effects. Tell your doctor right away if you have any of the following symptoms:

• Blood clots in the legs (deep-vein thrombosis)
  • Sudden swelling in a leg
  • Pain or tenderness in the leg, which might be felt only when standing or walking
  • Increased warmth in the area of the swelling
  • Skin redness or change in skin color
• Blood clots that travel to the lungs (pulmonary embolus)
  • Sudden sharp chest pain
  • Shortness of breath
  • Cough with bloody secretions
  • Rapid pulse
  • Fainting
  • Feeling anxious
  • Sweating
• Dehydration (loss of too much fluid from the body). This can happen if you are having nausea, vomiting, or diarrhea and cannot drink enough to replace the fluids.
• Low blood cell counts: Your doctor will periodically do blood tests to check your blood counts.
  • Low red blood cells. Low red blood cells may make you feel tired or get tired easily. You may look pale and feel short of breath.
  • Low platelets. Low platelets can cause unusual bleeding or bruising under the skin. Talk to your doctor right away if this happens.
• High blood sugar (blood glucose). If you have high blood sugar or diabetes, monitor your blood sugar frequently as directed by your doctor. Tell your doctor right away if your blood sugar is higher than normal.
• Electrocardiogram (EKG) abnormality. Your doctor will check your blood electrolytes and do an EKG periodically to check for abnormal electrical activity in your heart.

In addition, the most common side effects with ZOLINZA include:

• Stomach and intestinal problems, including diarrhea, nausea, vomiting, loss of appetite, constipation, and weight loss
• Fatigue (tiredness)
• Dizziness
• Headache
• Changes in the way things taste, and dry mouth
• Muscle aches
• Hair loss
• Chills
• Fever
• Upper respiratory infection
• Cough
• Increase in blood creatinine
• Swelling in the foot, ankle, and leg
• Itching

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of ZOLINZA. For more information, ask your doctor or pharmacist.

Learn more about managing common side effects, such as fatigue, diarrhea, nausea, changes in your sense of taste, and dry mouth.

Important information about ZOLINZA

ZOLINZA is a medicine used to treat a type of cancer called cutaneous T-cell lymphoma, also called CTCL. ZOLINZA is used in patients when the CTCL gets worse, does not go away, or comes back after treatment with other medicines.

• A possible serious side effect is an abnormality on your electrocardiogram, or EKG. Your doctor will check your blood electrolytes and EKG.
• The most common side effects of ZOLINZA include stomach problems, such as diarrhea, nausea, vomiting, loss of appetite, constipation, and weight loss; tiredness; taste changes; muscle aches; and hair loss.
• Your doctor will tell you how many ZOLINZA capsules to take and when to take them. Swallow each capsule whole; do not chew it or break it open. If you cannot swallow the capsules whole, tell your doctor. You may need a different medicine.
• ZOLINZA is available by prescription only.
• Please read the Patient Information for ZOLINZA and discuss it with your doctor. The physician Prescribing Information also is included on this site.
• You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.