SWAT Assessment Tool

The Severity-Weighted Assessment Tool (SWAT) used in the ZOLINZA pivotal trial is an objective, quantitative, severity-weighted method to assess the extent of CTCL lesions. A SWAT score is derived by measuring each lesion as a percentage of total body surface area (%TBSA) and multiplying it by a severity-weighting factor (1=patch, 2=plaque, 4=tumor). All individual numbers are then added to produce a total score. Among the patients in this trial, the median baseline SWAT score was 73.7 (range: 1.5–366.0).

• SWAT Methodology
• Modified SWAT Assessment Tool

SWAT Methodology

Quantitative Tool to Assess Disease Burden in CTCL¹
The body is divided into 12 regions with preassigned %TBSA based on methodology used to assess burns as shown in the figure below. The extent of skin disease is assessed for each region and quantified by using the patient's palm as a "ruler" to measure the %TBSA involvement within each region¹:

• Patient's palm with 4 fingers, excluding the thumb and measured from wrist to fingertips, is 1% of TBSA.
• Patient's palm without fingers is 0.5% of TBSA.

SWAT
% Total Body Surface Area (TBSA) for 12 Main Body Areas²

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Modified SWAT Assessment Tool

Area of skin involvement identified as patch, plaque, or tumor as defined in the table below:

Skin Lesion Definitions
Lesion Type	Abnormal Skin	Erythema
Patch	Abnormal skin not elevated from normal skin	Flat erythema or erythema with mild infiltration
Plaque	Abnormal skin elevated from normal skin by <5 mm	Elevated erythema or erythema with moderate infiltration
Tumor	Abnormal skin elevated from normal skin by ≥5 mm	Erythema with fissuring, ulceration, or tumor
SWAT Score Calculation

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